Fibrous histiocytoma is a benign soft tissue tumour that may present as a fibrous mass anywhere in the human body. Benign fibrous histiocytoma bfh are uncommon in the oral cavity but should be considered in the differential diagnosis of fibrous growth of gingiva and oral mucosa. Dermal dendrocytoma, dermatofibroma, fibrous dermatofibroma, fibrous histiocytoma, fibroma simplex, nodular subepidermal fibrosis, and sclerosing hemangioma. This case shares some features with the four cases previously described, viz.
The author of this site prefes the name benign fibrous histiocytoma. Benign fibrous histiocytoma of bone radiology reference. Cases of fibrous histiocytoma of the face have to be excised with wider margins in comparison with examples of classical fibrous histiocytoma occurring on the extremities because of diffuse infiltration, involvement of deeper structures, and an increased rate of local recurrences. Pathology outlines benign fibrous histiocytoma superficial. Its occurrence in the metacarpal bones is even rarer. Benign fibrous histiocytoma bfh most commonly occurs in the dermis and subcutis, few cases of this tumor appear in the renal capsule. Pleomorphic sarcoma malignant fibrous histiocytoma of. Benign fibrous histiocytomas bfh of the skin are common lesions, although they only rarely involve the oral mucosa. Malignant fibrous histiocytoma mfh, which has more recently been classified as pleomorphic undifferentiated sarcoma pus and formerly known as fibrosarcoma, is considered the most common type of soft tissue sarcoma. Webmd can tell you more about it and how its treated. Atypical fibrous histiocytoma is a distinctive variant of cutaneous fibrous histiocytoma, which is often mistaken histologically for sarcoma and which have a tendency to recur locally and a capacity to metastasize, although very rarely.
Malignant fibrous histiocytoma is the most common malignant soft tissue tumor in late adulthood. This process is experimental and the keywords may be updated as the learning algorithm improves. Pdf fibrous histiocytomas are divided into two subgroups. Deep fibrous histiocytoma surgical pathology criteria. Definition and pathogenesis a benign but locally persistent tumor composed of fibroblastic and histiocytic cells subdivided into. We report two cases of benign fibrous histiocytoma that localized in the oral cavity. Bfh rarely occurs in bone and may affect femur, tibia, and pelvic bone. Research revealed that the condition is 4 times more common in women than in men. A heterogeneous fibroblastic spindle cells, histiocytic, inflammatory and pleomorphic giant cells are scattered throughout the tumour mass embedded in myxoid stroma containing plentiful collagen fibres. If they are close to the surface of the body, they may appear as a lump. In addition to the common pattern, a number of variants are currently recognized some of which may mimic other benign or malignant lesions. Atypical fibrous histiocytoma immunohistochemistry.
A dermatofibroma, or benign fibrous histiocytomas, is a benign skin growth dermatofibroma. Histiocytoma benign fibrous histiocytoma pathology. Several histologic variants of cutaneous fh have been described, some of which also have distinct clinical features including a propensity for local recurrence. Epithelioid cell histiocytoma with sqstm1alk fusion.
The lesion had normal mucosal colouration, granular surface, was nonulcerated, firm on palpation, and was not associated with tenderness or discharge. Damato gutirrez m 2016 benign fibrous histiocytoma, case report hematol ed ncol, 2016 doi. It is otherwise known as epithelioid fibrous histiocytoma and epithelioid dermatofibroma. Dermatofibroma pictures, removal, symptoms, treatment. The clinical and histological features of the lesion are reported.
Pleomorphic sarcoma malignant fibrous histiocytoma of soft. Epithelioid cell histiocytoma is a well recognised variant of cutaneous fibrous histiocytoma that may be confused with other benign and malignant mesenchymal lesions. The authors present a case of bfh involving the second metacarpal bone. Benign fibrous histiocytoma of the trachea the journal. Mfh, benign fibrous histiocytoma bfh of the noncutaneous soft tissues of the head and neck has received little. Pdf benign fibrous histiocytoma of the trachea funda. Benign fibrous histiocytoma is a common soft tissue tumor that can be deep or superficially located. Pdf benign fibrous histiocytoma is an extremely rare spinal tumor with ten reported cases in the literature. Received for publication jtuy 3, 1978 fibrous histiocytotna is a generic term wliich defines a distinctive group of tumors having in common both fibrocytic and hisdocydc elements stout. A histologically benign but locally infiltrating tumor of histiocytes, fibrous histiocytoma, was found in the trachea of a 26yearold man. If you have pain or if the tumor grows, you should see a doctor. The management in this location can be challenging, involving tumour resection and metacarpal reconstruction. Finally, a literature revision of this pathology at the level of the oral cavity is reported. Printable deep fibrous histiocytoma surgical pathology.
Benign fibrous histiocytoma dermatofibroma of the face. They are composed of two cell types, namely atypical fibroblasts and histiocytes, arranged in a storiform pattern. Benign fibrous histiocytoma bfh most frequently occurs in the dermis and is rarely found in subcutaneous soft tissue, especially on the face. Benign fibrous histiocytoma of the trachea springerlink. We report a new case of atypical cutaneous fibrous histiocytoma in a 31yearold man who presented with a recurrent polypoid nodule on the abdominal wall.
Dermatofibromas occur at all ages and in people of every ethnicity. Dermatofibromas are hard solitary slowgrowing papules rounded bumps that may appear in a variety of colours, usually brownish to tan. Histiocytes are cells that are a part of the mononuclear phagocytic system, a part of the bodys immune system that consists of phagocytic cells, which are responsible for engulfing solid particles by the cell membrane to form an internal phagosome by phagocytes and protists types include. The clinical lesion is a firm tanbrown nodule most commonly found on the legs. Case report with immunohistochemical features author links open overlay panel fabio a. Most commonly this tumor occurs on the skin of the extremities. A portion of the confusion arises from the lack of agreement between pathologists as to what exactly defines this lesion.
Benign fibrous histiocytoma is a tumor mostly dealt with in ambulatory settings due to its often paucisimptomatic presentation and to the fact that clinicians may not always recognize its potential for metastasis and reccurence. Benign fibrous histiocytoma of the lumbar vertebrae. Fibrous histiocytoma has been found to form after a minor skin injury or insect bite. Lipidized fibrous histiocytoma presenting as a keloidlike lesiona case report fengling lin meichin ho shulin hu a 46yearold man presented with a gradually growing nodule on the left dorsal foot, which had been present for over 10 years. Must have at least areas of histologic features of usual dermal fibrous histiocytoma. Anyone can develop fibrous histiocytoma but it has been found to more frequently affect young adults than children. It is a benign tumor of the soft tissues which reveals moderate infiltrative capacity but. There is disagreement amongst pathologists as to whether this tumor represents a true neoplasm, adevelopmental defect, or a reactive process.
Benign fibrous histiocytoma of bone is a benign primary bone neoplasia characterized by a mixture of fibroblasts disposed in a predominant storiform fashion, a variable amount of osteoclasttype giant cells, foamy macrophages, hemosiderin, and chronic inflammatory infiltrate, a histologic picture indistinguishable from nonossifying fibroma. Benign fibrous histiocytoma is closely related to fibroxanthoma of bone, is a rare lesion usually occurring in the skin where it is known as dermatofibroma. Lipidized fibrous histiocytoma presenting as a keloidlike lesion. Benign fibrous histiocytoma bfh, a pleomorphic softtissue tumor characterized by the presence of histiocytes, fibroblasts, and myofibroblasts, was first. Dermatofibroma fibrous histiocytoma dermatology advisor.
Benign fibrous histiocytoma of a metacarpal bone bmj. A benign fibrous histiocytoma bfh involving the limbus is a rare type of tumor. We report a 64yearold man who presented with a fewmonths history of. Benign fibrous histiocytoma definition of benign fibrous. Malignant fibrous histiocytoma fibrous histiocytoma deep form sclerosing hemangioma wide surgical excision these keywords were added by machine and not by the authors. Deep benign fibrous histiocytoma is a benign soft tissue tumor occurring deep below the skin in 90% of the cases. Benign fibrous histiocytoma fh is one of the most common mesenchymal neoplasms of the skin.
Orbital fibrous histiocytoma, fibroma, solitary fibrous tumor, fibrosarcoma, fibromatosis, and nodular fasciitis are discussed in this article. Benign fibrous histiocytoma bfh is a common soft tissue tumour. Primary malignant fibrous histioeytoma of skin may have a prognosis superior to homologous tumors arising in deeper soft tissue and the retroperitoneum. Pdf benign fibrous histiocytoma fh is a benign tumor composed of fibroblasts and histiocytes in varying proportions. Pdf benign fibrous histiocytoma of maxillary gingiva. A histiocytoma is a tumour consisting of histiocytes. Dermatofibroma benign fibrous histiocytoma lecturio. Know the types, causes, signs, symptoms, treatment, prevention, prognosis, and complications of fibrous histiocytoma. Pathologic and mr imaging features of benign fibrous soft.
Chemotherapy, radiation therapy, andor targeted therapy may also be used. Benign fibrous histiocytoma bfh is a rare skeletal tumor, accounting for approximately 1% of all surgically managed benign bone tumors. The cutaneous benign fibrous histiocytoma is a solitary, slowly growing, asymptomatic pigmented papule that usually makes its appearence during early or midadult life, with a. Diagnostic approach to malignant fibrous histiocytomas of soft tissue in dogs. Fibrous tumors of the orbital soft tissues are relatively uncommon lesions that present a confusing clinical, histologic, and radiographic spectrum of disease. Epithelioid sarcoma resembling benign fibrous histiocytoma. Spinal location is very rare, and its management can be challenging, involving excision of tumor and spinal reconstruction and stabilization. Benign fibrous histiocytoma involving the ends of long bone. Malignant fibrous histiocytoma in the bones is a very rare cancer. Clinical features and treatment of fibrous histiocytomas.
From a diagnostic point of view, fibrous histiocytoma of the bone is not always characterized by a lesion that is easily notice. This paper presents a clinical and histological description of a case of fibrous histiocytoma at the level of the third tracheal ring. What is malignant fibrous histiocytoma in the bones. Benign fibrous histiocytoma of the trachea is a rare neoplasm. We describe 2 patients with unique clinicopathologic features that, to. Benign fibrous histiocytoma bfh is a rare skeletal tumour. It is seen most frequently on the lower extremities of young to middleaged adults.
Fibrous histiocytoma is of 2 types which includes benign and malignant. We herein report such a case, describing the clinical characteristics of the lesion, complete diagnostic evaluation, management, and followup. Benign fibrous histiocytoma bfh is a wellestablished soft tissue neoplasm that was described by stout and lattes 1 in 1967. The diagnosis of dermatofibroma df, also referred to as fibrous histiocytoma, is made clinically and confirmed histologically if warranted. The most common location is in the lower limbs, particularly the thigh region, where it can appear as a painless mass. Osteosarcoma and malignant fibrous histiocytoma mfh of the bone treatment usually involves surgery to remove the tumor.
Dermatofibroma is a common benign tumour also known as fibrous histiocytoma. Files are available under licenses specified on their description page. Skin nonmelanocytic tumor deep benign fibrous histiocytoma. These slowgrowing solitary tumors are generally welldefined, painless, and have a rare occurrence. Benign fibrous histiocytoma in a child a case report.
Benign fibrous histiocytoma of the corneoscleral limbus. This group is made up of a wide variety of conditions that can affect both children and adults. Dr amanda oakley, dermatologist, hamilton, new zealand, 1997. Clinical features and treatment of fibrous histiocytomas of the. We report a case of es on the right hand of a 23yearold man that histopathologically resembled a benign fibrous histiocytoma. Pdf subcutaneous benign fibrous histiocytoma showing. Neoplasms originating in the renal capsule are very rare. However, its occurrence in the orbit was not well recognised in the past. Histiocytic disorders are a group of diseases that occur when there is an overproduction of white blood cells known as histiocytes that can lead to organ damage and tumor formation.
Benign fibrous histiocytoma of the oralperioral regions. Issn 00015555 fibrous histiocytoma is a benign tumour composed of a mixture of fibroblastic and histiocytic cells and is one of the most common mesenchymal neoplasms of the skin 1, 2. A patient history of a solitary, slowgrowing cutaneous nodule on the extremities of young to middleaged adults, often female, is consistent with df. Pdf benign fibrous histiocytoma arising from the right shoulder. Benign fibrous histiocytoma bfh is a soft tissue neoplasm which occurs mostly on the skin of extremities. The benign fibrous histiocytoma bfh is a mesenchymal tumour that has been described as a benign neoplasm composed of fibroblasts and histiocytes arising in the cutaneous soft tissues. Clinical presentation typically presents with pain, and most often in the third decade. Undifferentiated pleomorphic sarcoma ups, previously called malignant fibrous histiocytoma mfh, is a soft tissue sarcoma sts that can occur anywhere in the body, but it usually occurs in the extremities especially the thighs or back of the abdomen see the image below. A benign tumour composed of primitive mesenchymal cells macrophages or histiocytes seen in the skin and soft tissues of the legs of young to middleaged patients, more commonly women, usually in relation to skeletal muscle. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Osteosarcoma and malignant fibrous histiocytoma of bone. Although the deep type of fibrous histiocytoma has a predilection for the orbit, the eyelids are an unusual location for the cutaneous type. A dermatofibroma is also called a cutaneous fibrous histiocytoma.
In epithelioid histiocytoma, sections show a centrally located, circumscribed tumour underlying an. Fibrous histiocytomas are benign fibrohistiocytic bfh tumors. Pdf deep benign fibrous histiocytoma in the oral cavity. Noncutaneous presentation is extremely limited, even more so for the mucosa of the head and neck area. All structured data from the file and property namespaces is available under the creative commons cc0 license. A dermatofibroma, or benign fibrous histiocytomas, is a benign skin growth.
Epithelioid cell histiocytoma ech, which is also known as epithelioid benign fibrous histiocytoma, is generally considered to be an epithelioid variant of fibrous histiocytoma fh of the skin 1,2,3,4. Prominent storiform pattern of uniform spindle cells with ill defined eosinophilic cytoplasm and bland, elongated or plump vesicular nuclei with no atypia. Epithelioid sarcoma es is a rare malignancy notorious for its tendency to histologically mimic granuloma annulare and other palisading granulomatous processes. We reported 2 cases, one aged 3 years and one 5 years, with endotracheal fibrous histiocytoma showing no clinical evidence of. The benign fibrous histiocytoma hfb or fibrohistiocytoma is one of the most common mesenchymal tumors in adults, but in children are few report cases. The clinical, radiologic, and pathological features of eight cases of fibrohistiocytic bone lesions histologically identical to the nonossifying fibroma of childhood are presented.
Fibrous histiocytoma is a benign tumour composed of a mixture of fibroblastic and histiocytic cells. A case report yukiyo toyohara1, susumu hashitani1, kazunari sakurai1,2, kazuki takaoka1 and masahiro urade1 1department of oral and maxillofacial surgery, hyogo college of medicine 2department of surgical pathology, hyogo college of medicine abstract. Pdf benign fibrous histiocytoma of the lumbar vertebrae. There is debate as to whether dermatofibroma has a reactive or neoplastic origin. Benign fibrous histiocytoma in the mandible sciencedirect. What is fibrous histiocytomatypescausestreatmentsurgery.
Benign fibrous histiocytoma of submandibular space pradipta kumar parida gopalakrishnan surianarayanan department of otorhinolaryngology and headneck surgery, jipmer, puducherry, india abstract. The lesion is mainly epidermal, but may show extension into the superficial subcutis. They differed from the childhood lesion in their clinical and radiological features. Dermatofibroma contains large amounts of collagen cutaneous fibrous histiocytoma bfh contains numerous phagocytic cells. Benign fibrous histiocytoma of bone portnotes orthopaedicsone. Epithelioid benign fibrous histiocytoma ebfh is a distinctive variant of fibrous histiocytoma initially described by wilson jones et al23 in 1989 as epithelioid cell. Lipidfilled cells may be conspicuous and occasionally are the major component. Pathology outlines deep benign fibrous histiocytoma. We present the case of a 4 years old male child operated for a tumor with very atypical localization adjacent to the sixth cervical vertebra, mobile on the.
Malignant fibrous histiocytoma radiology reference article. Do 1college of veterinary medicine and veterinary science research institute, konkuk university, seoul, republic of korea 2hyundae general animal hospital, seoul, republic of korea. Benign fibrous histiocytoma of bone definition and pathogenesis controversial, some probably gcts with fibrohistiocytic reparative reaction, some may be a nof in a nonlong bone site eg, ilium, rib, sacrum, vertebra, and some probably truely bfh. Benign fibrous histiocytoma of the eyelid with an unusual. Note that this was not considered a criterion for atypical fibrous histiocytoma in the publication of gleason 2008, but one of their two cases with tumor cell necrosis metastasized. In the beginning, the lesion was treated as a keloid. Atypical fibrous histiocytoma, pseudosarcomatous fibrous histiocytoma, dermatofibroma with monster cells clinical features this is a relatively uncommon lesion. Nov 07, 2018 undifferentiated pleomorphic sarcoma ups, previously called malignant fibrous histiocytoma mfh, is a soft tissue sarcoma sts that can occur anywhere in the body, but it usually occurs in the extremities especially the thighs or back of the abdomen see the image below. Benign fibrous histiocytoma portnotes orthopaedicsone.
Benign fibrous histiocytoma of the thoracic spine in. Variable hemosiderin, multinucleated giant cells, chronic. Subcutaneous benign fibrous histiocytoma of the cheek. Dec 17, 2009 fibrous histiocytoma is a benign soft tissue tumour arising as a fibrous mass everywhere in the human body. Apr 06, 2018 fibrous histiocytoma is an infrequent type of sarcoma of uncertain basis that appears both in bone and soft tissue.
Dermatofibroma benign fibrous histiocytoma is a common skin lesion and it accounts for approximately 3% of the skin lesion specimens received by one derma. Ech is a dermalbased benign fibrohistiocytic tumor, which can mimic melanocytic, vascular, epithelial, and other histiocytic lesions. Histopathological and immunohistochemical findings of the recurrent lesion diagnosed as malignant fibrous histiocytoma of myxoid type. Fibrous histiocytoma is a benign soft tissue tumour arising as a fibrous mass everywhere in the human body. Benign fibrous histiocytoma is a rare tumor of mesenchymal origin. Neoplasm with features of usual dermal fibrous histiocytoma but occuring in subcutaneous or deep soft tissue. Introduction benign fibrous histiocytomas are common lesions of the skin that rarely. Transformation of benign fibrous histiocytoma into. Diagnostic approach to malignant fibrous histiocytomas of. Benign fibrous histiocytoma is an interesting and challenging entity even in its most usual, cutaneous presentation.
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